Dauricine

Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer.

Product information

CAS Number: 524-17-4

Molecular Weight: 624.77

Formula: C38H44N2O6

Chemical Name: 4-{[(1R)-6, 7-dimethoxy-2-methyl-1, 2, 3, 4-tetrahydroisoquinolin-1-yl]methyl}-2-(4-{[(1R)-6, 7-dimethoxy-2-methyl-1, 2, 3, 4-tetrahydroisoquinolin-1-yl]methyl}phenoxy)phenol

Smiles: CN1CCC2=CC(OC)=C(C=C2[C@H]1CC1=CC(OC2C=CC(C[C@@H]3C4=CC(OC)=C(C=C4CCN3C)OC)=CC=2)=C(O)C=C1)OC

InChiKey: AQASRZOCERRGBL-ROJLCIKYSA-N

InChi: InChI=1S/C38H44N2O6/c1-39-15-13-26-20-35(42-3)37(44-5)22-29(26)31(39)17-24-7-10-28(11-8-24)46-34-19-25(9-12-33(34)41)18-32-30-23-38(45-6)36(43-4)21-27(30)14-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75.

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