Description
AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.
Product information
CAS Number: 1416799-28-4
Molecular Weight: 453.32
Formula: C20H12F5N3O4
Chemical Name: 6-({[3-fluoro-4-(trifluoromethoxy)phenyl](3-fluoropyridin-2-yl)methyl}carbamoyl)pyridine-3-carboxylic acid
Smiles: OC(=O)C1=CN=C(C=C1)C(=O)NC(C1N=CC=CC=1F)C1=CC(F)=C(C=C1)OC(F)(F)F
InChiKey: QEBYISWYMFIXOZ-UHFFFAOYSA-N
InChi: InChI=1S/C20H12F5N3O4/c21-12-2-1-7-26-17(12)16(10-4-6-15(13(22)8-10)32-20(23,24)25)28-18(29)14-5-3-11(9-27-14)19(30)31/h1-9,16H,(H,28,29)(H,30,31)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Solubility (25°C). 91 mg/mL(200.74 mM). Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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