Butyrolactone 3


Catalog No. Size PriceQuantity
M13999-2 2mg solid $310
M13999-10 10mg solid $1,240

Description

Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)

Product information

CAS Number: 778649-18-6

Molecular Weight: 184.19

Formula: C9H12O4

Chemical Name: (2R,3S)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid

Smiles: CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O

InChiKey: SRQUTZJZABSZRQ-RQJHMYQMSA-N

InChi: InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6

Products are for research use only. Not for human use.

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