Description
Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 2093153-98-9
Molecular Weight: 451.55
Formula: C21H41NO9
Chemical Name: 3,6,9,12,15,18,21,24,27-nonaoxatriacont-29-yn-1-amine
Smiles: C#CCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
InChiKey: HWOGUEROMVALKI-UHFFFAOYSA-N
InChi: InChI=1S/C21H41NO9/c1-2-4-23-6-8-25-10-12-27-14-16-29-18-20-31-21-19-30-17-15-28-13-11-26-9-7-24-5-3-22/h1H,3-22H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.
Products are for research use only. Not for human use.
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