Description
J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1.
Product information
CAS Number: 2252395-44-9
Molecular Weight: 415.44
Formula: C24H21N3O4
Chemical Name: 4-{[2,4-dioxo-3-(2-phenylethyl)-1,2,3,4-tetrahydroquinazolin-1-yl]methyl}-N-hydroxybenzamide
Smiles: ONC(=O)C1C=CC(CN2C3=CC=CC=C3C(=O)N(CCC3C=CC=CC=3)C2=O)=CC=1
InChiKey: JBJIKUXUKSADFV-UHFFFAOYSA-N
InChi: InChI=1S/C24H21N3O4/c28-22(25-31)19-12-10-18(11-13-19)16-27-21-9-5-4-8-20(21)23(29)26(24(27)30)15-14-17-6-2-1-3-7-17/h1-13,31H,14-16H2,(H,25,28)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (300.89 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
J22352 (0.1-20 μM; 72 hours) decreases U87MG cell viability in a dose-dependent manner. J22352 (10 μM; 24 hours) shows a dose-dependent decrease in HDAC6 protein abundance.
In Vivo:
J22352 (10 mg/kg; given i.p. per day for 14 days in male nude mice) results in a >80% tumor growth inhibition (TGI) rate. J22352 is well tolerated in mice.
Products are for research use only. Not for human use.
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