BR351


Catalog No. Size PriceQuantity
M14158-2 Contact sales@xcessbio.com for quotation $100

Description

BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.

Product information

CAS Number: 960113-85-3

Molecular Weight: 424.49

Formula: C20H25FN2O5S

Chemical Name: (2R)-2-[N-benzyl4-(2-fluoroethoxy)benzenesulfonamido]-N-hydroxy-3-methylbutanamide

Smiles: CC(C)[C@H](C(=O)NO)N(CC1=CC=CC=C1)S(=O)(=O)C1=CC=C(C=C1)OCCF

InChiKey: NSDMBIOAMTZMED-LJQANCHMSA-N

InChi: InChI=1S/C20H25FN2O5S/c1-15(2)19(20(24)22-25)23(14-16-6-4-3-5-7-16)29(26,27)18-10-8-17(9-11-18)28-13-12-21/h3-11,15,19,25H,12-14H2,1-2H3,(H,22,24)/t19-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50(23):5752-64.

Products are for research use only. Not for human use.

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