BRD9185


Catalog No. Size PriceQuantity
M14196-2 Contact sales@xcessbio.com for quotation $100

Description

BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model.

Product information

CAS Number: 2057420-29-6

Molecular Weight: 485.42

Formula: C23H21F6N3O2

Chemical Name: (2S,3S,4S)-3-[3',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl]-2-cyano-4-(hydroxymethyl)-N-propylazetidine-1-carboxamide

Smiles: CCCNC(=O)N1[C@H](C#N)[C@@H]([C@H]1CO)C1C=CC(=CC=1)C1C=C(C(=CC=1)C(F)(F)F)C(F)(F)F

InChiKey: FYPZBZFXJUJJRA-AQNXPRMDSA-N

InChi: InChI=1S/C23H21F6N3O2/c1-2-9-31-21(34)32-18(11-30)20(19(32)12-33)14-5-3-13(4-6-14)15-7-8-16(22(24,25)26)17(10-15)23(27,28)29/h3-8,10,18-20,33H,2,9,12H2,1H3,(H,31,34)/t18-,19-,20+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Maetani M, et al. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017 Feb 27;8(4):438-442.

Products are for research use only. Not for human use.

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