Ombitasvir (ABT-267)


Catalog No. Size PriceQuantity
M14227-2 Contact sales@xcessbio.com for quotation $100

Description

Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity.

Product information

CAS Number: 1258226-87-7

Molecular Weight: 894.11

Formula: C50H67N7O8

Chemical Name: methyl N-{1-[2-({4-[1-(4-tert-butylphenyl)-5-[4-(1-{2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidine-2-amido)phenyl]pyrrolidin-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Smiles: CC(C)(C)C1C=CC(=CC=1)N1C(CCC1C1C=CC(=CC=1)NC(=O)C1CCCN1C(=O)C(NC(=O)OC)C(C)C)C1C=CC(=CC=1)NC(=O)C1CCCN1C(=O)C(NC(=O)OC)C(C)C

InChiKey: PIDFDZJZLOTZTM-UHFFFAOYSA-N

InChi: InChI=1S/C50H67N7O8/c1-30(2)42(53-48(62)64-8)46(60)55-28-10-12-40(55)44(58)51-35-20-14-32(15-21-35)38-26-27-39(57(38)37-24-18-34(19-25-37)50(5,6)7)33-16-22-36(23-17-33)52-45(59)41-13-11-29-56(41)47(61)43(31(3)4)54-49(63)65-9/h14-25,30-31,38-43H,10-13,26-29H2,1-9H3,(H,51,58)(H,52,59)(H,53,62)(H,54,63)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Solubility (25°C). 100 mg/mL(111.84 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Ombitasvir (ABT-267) is a hepatitis C virus (HCV) NS5A inhibitor with picomolar potency, pan-genotypic activity, and 50% effective concentrations (EC50s) of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. Ombitasvir has EC50s of 14.1 and 5.0 pM against genotype 1a-H77 and 1b-Con1 subgenomic replicons, respectively.

Products are for research use only. Not for human use.

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