Description
XY1 is an inactive, close analog of SGC707 that can be used as the negative control for SGC707. SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.
Product information
CAS Number: 1624117-53-8
Molecular Weight: 297.35
Formula: C17H19N3O2
Chemical Name: 1-(naphthalen-2-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea
Smiles: O=C(CNC(=O)NC1=CC2=CC=CC=C2C=C1)N1CCCC1
InChiKey: GSQHGSRPQHBTTP-UHFFFAOYSA-N
InChi: InChI=1S/C17H19N3O2/c21-16(20-9-3-4-10-20)12-18-17(22)19-15-8-7-13-5-1-2-6-14(13)11-15/h1-2,5-8,11H,3-4,9-10,12H2,(H2,18,19,22)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Solubility (25°C). 59 mg/mL(198.41 mM). ˂1 mg/mL.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Kaniskan H?, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.
Products are for research use only. Not for human use.
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