Bometolol Hydrochloride

Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease.

Product information

CAS Number: 65023-16-7

Molecular Weight: 508.99

Formula: C25H33ClN2O7

Chemical Name: 5-(3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-hydroxypropoxy)-8-(2-oxopropoxy)-1,2,3,4-tetrahydroquinolin-2-one; chlorohydrogen

Smiles: Cl.CC(=O)COC1=CC=C(OCC(O)CNCCC2C=C(OC)C(=CC=2)OC)C2CCC(=O)NC=21

InChiKey: KCHIAYQOQVIORJ-UHFFFAOYSA-N

InChi: InChI=1S/C25H32N2O7.ClH/c1-16(28)14-33-22-8-7-20(19-5-9-24(30)27-25(19)22)34-15-18(29)13-26-11-10-17-4-6-21(31-2)23(12-17)32-3;/h4,6-8,12,18,26,29H,5,9-11,13-15H2,1-3H3,(H,27,30);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Bometolol (10-30 mg/kg, p.o.) lowers the blood pressure dose-dependently in spontaneously hypertensive rats, deoxycorticosterone and salt hypertensive rats and two kindey, one clip hypertensive rats. In subchronic study, Bometolol (10-30 mg/kg, or 100-300 mg/kg, p.o.) dose-dependently decreases heart rate, plasma renin activity, heart and kindey weitht and incidence of vascular lesion, but shows no antihypertensive effects in all the hypertensive rats.

References:

1. Watanabe TX, et al. Acute and subchronic effects of bometolol on blood pressure in hypertensive rats. J Pharmacobiodyn. 1981 Jul;4(7):505-12.

Products are for research use only. Not for human use.