Bis-PEG6-acid


Catalog No. Size PriceQuantity
M14278-2 2mg solid $80
M14278-10 10mg solid $240

Description

Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 119189-70-7

Molecular Weight: 382.40

Formula: C16H30O10

Chemical Name: 4,7,10,13,16,19-hexaoxadocosanedioic acid

Smiles: OC(=O)CCOCCOCCOCCOCCOCCOCCC(O)=O

InChiKey: YFBGEYNLLRKUTP-UHFFFAOYSA-N

InChi: InChI=1S/C16H30O10/c17-15(18)1-3-21-5-7-23-9-11-25-13-14-26-12-10-24-8-6-22-4-2-16(19)20/h1-14H2,(H,17,18)(H,19,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

  1. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.

Products are for research use only. Not for human use.

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