Description
Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 119189-70-7
Molecular Weight: 382.40
Formula: C16H30O10
Chemical Name: 4,7,10,13,16,19-hexaoxadocosanedioic acid
Smiles: OC(=O)CCOCCOCCOCCOCCOCCOCCC(O)=O
InChiKey: YFBGEYNLLRKUTP-UHFFFAOYSA-N
InChi: InChI=1S/C16H30O10/c17-15(18)1-3-21-5-7-23-9-11-25-13-14-26-12-10-24-8-6-22-4-2-16(19)20/h1-14H2,(H,17,18)(H,19,20)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.
Products are for research use only. Not for human use.
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