Benzoylhypaconine

Benzoylhypaconine (Benzoylhypacoitine) is a monoester Aconitum alkaloid, is the main pharmacologic and toxic component.

Product information

CAS Number: 63238-66-4

Molecular Weight: 573.67

Formula: C31H43NO9

Synonym:

Benzoylhypacoitine

Chemical Name: (2R,3R,4R,5R,6S,7S,8R,13S,16S,17R,18R)-2,3,17-trihydrogenio-5,7,8-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-methyl-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecan-4-yl benzoate

Smiles: CN1C[C@@]2(CC[C@H](OC)C34[C@@H]2[C@@H](OC)C(C31)[C@]1(O)[C@H]2[C@@H](OC(=O)C3C=CC=CC=3)[C@](O)(C[C@@H]42)[C@@H](OC)[C@@H]1O)COC

InChiKey: MDFCJNFOINXVSU-LUOWNJJZSA-N

InChi: InChI=1S/C31H43NO9/c1-32-14-28(15-37-2)12-11-18(38-3)30-17-13-29(35)25(41-27(34)16-9-7-6-8-10-16)19(17)31(36,24(33)26(29)40-5)20(23(30)32)21(39-4)22(28)30/h6-10,17-26,33,35-36H,11-15H2,1-5H3/t17-,18+,19-,20?,21+,22-,23?,24+,25-,26+,28+,29-,30?,31-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (174.32 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Aconitum alkaloids have narrow therapeutic indices. Their potential toxicity, which is caused by hyperpolarization and activation of voltage-dependent sodium and calcium channels, can result in fatal cardiac poisoning and neurotoxicity.

References:

1. Song S, et al. Simultaneous quantification and pharmacokinetics of alkaloids in Herba Ephedrae-Radix Aconiti Lateralis extracts. J Anal Toxicol. 2015 Jan-Feb;39(1):58-68.

Products are for research use only. Not for human use.