BI-3802


Catalog No. Size PriceQuantity
M14366-2 Contact sales@xcessbio.com for quotation $100

Description

BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity.

Product information

CAS Number: 2166387-65-9

Molecular Weight: 484.98

Formula: C24H29ClN6O3

Chemical Name: 2-{[6-({5-chloro-2-[(3R,5S)-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl}amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl]oxy}-N-methylacetamide

Smiles: CN1C2C=CC(=CC=2C=C(OCC(=O)NC)C1=O)NC1=NC(=NC=C1Cl)N1C[C@H](C)C[C@H](C)C1

InChiKey: GXTJETQFYHZHNB-GASCZTMLSA-N

InChi: InChI=1S/C24H29ClN6O3/c1-14-7-15(2)12-31(11-14)24-27-10-18(25)22(29-24)28-17-5-6-19-16(8-17)9-20(23(33)30(19)4)34-13-21(32)26-3/h5-6,8-10,14-15H,7,11-13H2,1-4H3,(H,26,32)(H,27,28,29)/t14-,15+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5 mg/mL (10.31 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BI-3802 shows an IC50 of 43 nM for the cellular BCL6. BI-3802 increases the interaction between BCL6 and SIAH1 (EC50 = 64 nM).

Products are for research use only. Not for human use.

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