Semilicoisoflavone B


Catalog No. Size PriceQuantity
M14547-2 Contact sales@xcessbio.com for quotation $100

Description

Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation.

Product information

CAS Number: 129280-33-7

Molecular Weight: 352.34

Formula: C20H16O6

Chemical Name: 5,7,8'-trihydroxy-2',2'-dimethyl-2'H,4H-[3,6'-bichromen]-4-one

Smiles: CC1(C)C=CC2=CC(=CC(O)=C2O1)C1=COC2=CC(O)=CC(O)=C2C1=O

InChiKey: LWZACZCRAUQSLH-UHFFFAOYSA-N

InChi: InChI=1S/C20H16O6/c1-20(2)4-3-10-5-11(6-15(23)19(10)26-20)13-9-25-16-8-12(21)7-14(22)17(16)18(13)24/h3-9,21-23H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Gu MY, et al. Glycyrrhiza uralensis and Semilicoisoflavone B Reduce Aβ Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression. Mol Nutr Food Res. 2018 Mar;62(6):e1700633.

Products are for research use only. Not for human use.

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