Description
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment.
Product information
CAS Number: 3486-67-7
Molecular Weight: 352.40
Formula: C21H22NO4
Chemical Name: 3,4,10,11-tetramethoxy-7,8-dihydro-6λ⁵-azatetraphen-6-ylium
Smiles: COC1C=C2C3C=C4C=CC(OC)=C(OC)C4=C[N+]=3CCC2=CC=1OC
InChiKey: QUCQEUCGKKTEBI-UHFFFAOYSA-N
InChi: InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM.
In Vivo:
Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity.
References:
- Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46.
Products are for research use only. Not for human use.
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