Description
Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604).
Product information
CAS Number: 2143096-93-7
Molecular Weight: 973.63
Formula: C47H56ClF3N6O5S3
Chemical Name: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-1-(phenylsulfanyl)-4-(piperazin-1-yl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide
Smiles: CC1(C)CCC(=C(C1)CN1CCN(CC1)C1C=CC(=CC=1)C(=O)NS(=O)(=O)C1C=C(C(=CC=1)N[C@@H](CSC1C=CC=CC=1)CCN1CCNCC1)S(=O)(=O)C(F)(F)F)C1C=CC(Cl)=CC=1
InChiKey: CRPNZDFOWRFBLZ-KXQOOQHDSA-N
InChi: InChI=1S/C47H56ClF3N6O5S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-56-26-28-57(29-27-56)39-14-10-35(11-15-39)45(58)54-65(61,62)41-16-17-43(44(30-41)64(59,60)47(49,50)51)53-38(19-23-55-24-21-52-22-25-55)33-63-40-6-4-3-5-7-40/h3-17,30,38,52-53H,18-29,31-33H2,1-2H3,(H,54,58)/t38-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (256.77 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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