GNE-8324


Catalog No. Size PriceQuantity
M14821-2 Contact sales@xcessbio.com for quotation $100

Description

GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons.

Product information

CAS Number: 1698901-76-6

Molecular Weight: 343.42

Formula: C18H18FN3OS

Chemical Name: 10-{[ethyl(4-fluorophenyl)amino]methyl}-7-thia-1,9-diazatricyclo[6.4.0.0²,⁶]dodeca-2(6),8,10-trien-12-one

Smiles: CCN(CC1=CC(=O)N2C(=N1)SC1CCCC2=1)C1C=CC(F)=CC=1

InChiKey: MKBFOAQLSFHEGN-UHFFFAOYSA-N

InChi: InChI=1S/C18H18FN3OS/c1-2-21(14-8-6-12(19)7-9-14)11-13-10-17(23)22-15-4-3-5-16(15)24-18(22)20-13/h6-10H,2-5,11H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

A reciprocal allosteric interaction between the GNE-8324 and glutamate binding sites at GluN2A NMDARs such that binding of glutamate enhances binding of GNE-8324 and vice versa. GNE-8324 selectively potentiates GluN2A subunit-containing NMDARs. As a consequence, GNE-8324 potentiation is highly dependent on glutamate site occupancy with enhanced GNE-8324 binding to glutamate-bound NMDARs compared to glutamate-free NMDARs.

Products are for research use only. Not for human use.

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