Description
Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM).
Product information
CAS Number: 2250025-95-5
Molecular Weight: 377.31
Formula: C19H22Cl2N4
Chemical Name: N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine; chlorohydrogen
Smiles: Cl.ClC1=CC(CNC2=NC3C=CC=CC=3NC32CCNCC3)=CC=C1
InChiKey: HEHOHTKMIOBTKC-UHFFFAOYSA-N
InChi: InChI=1S/C19H21ClN4.ClH/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18;/h1-7,12,21,24H,8-11,13H2,(H,22,23);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Liproxstatin-1 shows antiferroptotic activity with an IC50 of approximately 38 nM in mouse embryonic fibroblasts.
In Vivo:
Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4-/- kidney and in an ischaemia/reperfusion-induced tissue injury model.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.