CB2R PAM


Catalog No. Size PriceQuantity
M15053-2 Contact sales@xcessbio.com for quotation $100

Description

CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain.

Product information

CAS Number: 2244579-87-9

Molecular Weight: 435.33

Formula: C21H24BrFN2O2

Chemical Name: N-{5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxo-1,2-dihydropyridin-3-yl}cycloheptanecarboxamide

Smiles: CC1C(Br)=CN(CC2C=CC(F)=CC=2)C(=O)C=1NC(=O)C1CCCCCC1

InChiKey: NSGDYZCDUPSTQT-UHFFFAOYSA-N

InChi: InChI=1S/C21H24BrFN2O2/c1-14-18(22)13-25(12-15-8-10-17(23)11-9-15)21(27)19(14)24-20(26)16-6-4-2-3-5-7-16/h8-11,13,16H,2-7,12H2,1H3,(H,24,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs.

In Vivo:

CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity.

Products are for research use only. Not for human use.

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