3, 6-DMAD hydrochloride(x)

3,6-DMAD hydrochloride is a inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response.

Product information

Molecular Weight: 365.52

Formula: C22H31N5

Chemical Name: 9-N-[3-(dimethylamino)propyl]-3-N, 3-N, 6-N, 6-N-tetramethylacridine-3, 6, 9-triamine hydrochloride

Smiles: CN(C)CCCNC1C2=CC=C(C=C2N=C2C=C(C=CC2=1)N(C)C)N(C)C

InChiKey: UIWOQSJSDYDIQJ-UHFFFAOYSA-N

InChi: InChI=1S/C22H31N5/c1-25(2)13-7-12-23-22-18-10-8-16(26(3)4)14-20(18)24-21-15-17(27(5)6)9-11-19(21)22/h8-11,14-15H,7,12-13H2,1-6H3,(H,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 25 mg/mL (Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

3,6-DMAD inhibits both IRE1α oligomerization and in vitro endoribonuclease (RNase) activity.

In Vivo:

Following three intraperitoneal administrations of 3,6-DMAD at a dose of 10 mg/kg every 12 hours, 3,6-DMAD significantly inhibits in vivo XBP1-luciferase activity assessed 3.5 days after the initial treatment. 3,6-DMAD-treatment significantly inhibits tumor xenograft growth.

Products are for research use only. Not for human use.