GLP-26


Catalog No. Size PriceQuantity
M15124-2 Contact sales@xcessbio.com for quotation $100

Description

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools.

Product information

CAS Number: 2133017-36-2

Molecular Weight: 373.35

Formula: C19H17F2N3O3

Chemical Name: N-(3,4-difluorophenyl)-1,3,5-trimethyl-4-{[(prop-2-yn-1-yl)carbamoyl]carbonyl}-1H-pyrrole-2-carboxamide

Smiles: CC1=C(C(=O)C(=O)NCC#C)C(C)=C(C(=O)NC2C=C(F)C(F)=CC=2)N1C

InChiKey: SQOFSIXYJGPNKV-UHFFFAOYSA-N

InChi: InChI=1S/C19H17F2N3O3/c1-5-8-22-19(27)17(25)15-10(2)16(24(4)11(15)3)18(26)23-12-6-7-13(20)14(21)9-12/h1,6-7,9H,8H2,2-4H3,(H,22,27)(H,23,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (334.81 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV wild type, with EC50 values of 0.7 μM.

Products are for research use only. Not for human use.

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