Description
GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools.
Product information
CAS Number: 2133017-36-2
Molecular Weight: 373.35
Formula: C19H17F2N3O3
Chemical Name: N-(3,4-difluorophenyl)-1,3,5-trimethyl-4-{[(prop-2-yn-1-yl)carbamoyl]carbonyl}-1H-pyrrole-2-carboxamide
Smiles: CC1=C(C(=O)C(=O)NCC#C)C(C)=C(C(=O)NC2C=C(F)C(F)=CC=2)N1C
InChiKey: SQOFSIXYJGPNKV-UHFFFAOYSA-N
InChi: InChI=1S/C19H17F2N3O3/c1-5-8-22-19(27)17(25)15-10(2)16(24(4)11(15)3)18(26)23-12-6-7-13(20)14(21)9-12/h1,6-7,9H,8H2,2-4H3,(H,22,27)(H,23,26)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (334.81 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV wild type, with EC50 values of 0.7 μM.
Products are for research use only. Not for human use.
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