BOS-172722

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer.

Product information

CAS Number: 1578245-44-9

Molecular Weight: 446.55

Formula: C24H30N8O

Chemical Name: N8-(2,2-dimethylpropyl)-N2-[2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamine

Smiles: CC1=CC2=CN=C(NC3=CC=C(C=C3OCC)C3=NN=CN3C)N=C2C(NCC(C)(C)C)=N1

InChiKey: SGWLRDAOCLITOM-UHFFFAOYSA-N

InChi: InChI=1S/C24H30N8O/c1-7-33-19-11-16(22-31-27-14-32(22)6)8-9-18(19)29-23-25-12-17-10-15(2)28-21(20(17)30-23)26-13-24(3,4)5/h8-12,14H,7,13H2,1-6H3,(H,26,28)(H,25,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5 mg/mL (11.20 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM. BOS-172722 also has potential for the treatment of various forms of breast cancer.

In Vivo:

BOS-172722 shows excellent PK in mouse, rat, and dog. BOS-172722 (50 mg/kg) results in an increased suppression of MPS1 autophosphorylation at 6 and 24 h.

Products are for research use only. Not for human use.