Description
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.
Product information
CAS Number: 175340-20-2
Molecular Weight: 224.28
Formula: C10H12N2O2S
Chemical Name: (6S)-6-hydrogenio-8λ⁶-thia-2,7-diazatricyclo[7.4.0.0²,⁶]trideca-1(13),9,11-triene-8,8-dione
Smiles: O=S1(=O)N[C@H]2CCCN2C2=CC=CC=C12
InChiKey: MNTIJYGEITVWHU-SNVBAGLBSA-N
InChi: InChI=1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models . S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation.
Products are for research use only. Not for human use.
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