AZ1495


Catalog No. Size PriceQuantity
M15612-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).

Product information

CAS Number: 2196204-23-4

Molecular Weight: 385.50

Formula: C21H31N5O2

Chemical Name: 5-(oxan-4-yl)-N-[(1r,4r)-4-(morpholin-4-yl)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Smiles: C1C[C@H](CC[C@@H]1N1CCOCC1)NC1=NC=NC2NC=C(C3CCOCC3)C=21

InChiKey: DJVYXMINSBMUHH-QAQDUYKDSA-N

InChi: InChI=1S/C21H31N5O2/c1-3-17(26-7-11-28-12-8-26)4-2-16(1)25-21-19-18(15-5-9-27-10-6-15)13-22-20(19)23-14-24-21/h13-17H,1-12H2,(H2,22,23,24,25)/t16-,17-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 10 mg/mL (25.94 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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