Description
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities.
Product information
CAS Number: 20229-56-5
Molecular Weight: 464.38
Formula: C21H20O12
Chemical Name: 3,5,7-trihydroxy-2-(3-hydroxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-4H-chromen-4-one
Smiles: OC[C@H]1O[C@@H](OC2=CC=C(C=C2O)C2OC3=CC(O)=CC(O)=C3C(=O)C=2O)[C@H](O)[C@@H](O)[C@@H]1O
InChiKey: OIUBYZLTFSLSBY-HMGRVEAOSA-N
InChi: InChI=1S/C21H20O12/c22-6-13-15(26)17(28)19(30)21(33-13)32-11-2-1-7(3-9(11)24)20-18(29)16(27)14-10(25)4-8(23)5-12(14)31-20/h1-5,13,15,17,19,21-26,28-30H,6H2/t13-,15-,17+,19-,21-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversed by LY294002). Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis. Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG. Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway.
In Vivo:
Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability.
Products are for research use only. Not for human use.
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