OBAA


Catalog No. Size PriceQuantity
M15788-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM.

Product information

CAS Number: 134531-42-3

Molecular Weight: 428.65

Formula: C28H44O3

Chemical Name: (2E)-4-(4-octadecylphenyl)-4-oxobut-2-enoic acid

Smiles: CCCCCCCCCCCCCCCCCCC1C=CC(=CC=1)C(=O)/C=C/C(O)=O

InChiKey: ZBESASFHIWDSCJ-WCWDXBQESA-N

InChi: InChI=1S/C28H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-25-19-21-26(22-20-25)27(29)23-24-28(30)31/h19-24H,2-18H2,1H3,(H,30,31)/b24-23+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells had disintegrated into apoptotic bodies.

In Vivo:

The immunologically induced bronchospasm in guinea pigs is significantly and dose-dependently inhibited by OBAA (2.5-7 mg/kg i.v.).

Products are for research use only. Not for human use.

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