Isobutyl-deoxynyboquinone


Catalog No. Size PriceQuantity
M15791-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer.

Product information

CAS Number: 1430798-22-3

Molecular Weight: 326.35

Formula: C18H18N2O4

Chemical Name: 4,6-dimethyl-1-(2-methylpropyl)-1H,2H,5H,8H,9H,10H-pyrido[3,2-g]quinoline-2,5,8,10-tetrone

Smiles: CC1=CC(=O)N(CC(C)C)C2=C1C(=O)C1=C(NC(=O)C=C1C)C2=O

InChiKey: XVXDZGBARWYTHG-UHFFFAOYSA-N

InChi: InChI=1S/C18H18N2O4/c1-8(2)7-20-12(22)6-10(4)14-16(20)18(24)15-13(17(14)23)9(3)5-11(21)19-15/h5-6,8H,7H2,1-4H3,(H,19,21)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Isobutyl-deoxynyboquinone (0.01~100 μM; OSCC cells) demonstrates greater cytotoxic potency against SCCF1 and SCCF2 cell lines, and less against the SCCF3 cell line. Isobutyl-deoxynyboquinone (0.1~3 μM; 60 minutes; SCCF1 cells) induces cytotoxicity in a dose-dependent manner.

In Vivo:

Isobutyl-deoxynyboquinone (0.5~2 mg/kg; i.v.; 20 hours) achieves average peak plasma concentration levels. Isobutyl-deoxynyboquinone (1 mg/kg; p.o.; 4 hours) achieves peak plasma concentrations.

Products are for research use only. Not for human use.

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