1'-Hydroxymidazolam


Catalog No. Size PriceQuantity
M15912-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam.

Product information

CAS Number: 59468-90-5

Molecular Weight: 341.77

Formula: C18H13ClFN3O

Chemical Name: [12-chloro-9-(2-fluorophenyl)-2,4,8-triazatricyclo[8.4.0.0²,⁶]tetradeca-1(14),3,5,8,10,12-hexaen-3-yl]methanol

Smiles: OCC1=NC=C2CN=C(C3=CC(Cl)=CC=C3N12)C1=CC=CC=C1F

InChiKey: QHSMEGADRFZVNE-UHFFFAOYSA-N

InChi: InChI=1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

1'-Hydroxymidazolam (5 nM-1 µM) induces a significant inhibition of the action potential firing rate at concentrations of 100 nM or higher and causes a steady increase in the depression of network activity with increasing concentrations of up to 1 µM in neocortical slice cultures from wild-type mice.

Products are for research use only. Not for human use.

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