A 71915

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.

Product information

CAS Number: 132956-87-7

Molecular Weight: 1613.95

Formula: C69H116N26O15S2

Chemical Name: 2-[(6R,7R,11R,14S,23R,26S,29S,32S,35S,43aR)-11-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-26,35-bis[(2S)-butan-2-yl]-6-carbamoyl-14-(cyclohexylmethyl)-7,23,32-tris({3-[(diaminomethylidene)amino]propyl})-1,4,12,15,18,21,24,27,30,33,36-undecaoxo-1H,2H,3H,4H,5H,6H,7H,10H,11H,12H,13H,14H,15H,16H,17H,18H,19H,20H,21H,22H,23H,24H,25H,26H,27H,28H,29H,30H,31H,32H,33H,34H,35H,36H,38H,43H,43aH-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriaconta[11,10-b]isoquinolin-29-yl]acetic acid

Smiles: C[C@@H](CC)[C@@H]1NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2CCCCC2)NC(=O)[C@H](CSS[C@H](CCCN=C(N)N)[C@H](NC(=O)CNC(=O)[C@H]2CC3=CC=CC=C3CN2C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)CC)C(N)=O)NC(=O)[C@@H](N)CCCN=C(N)N

InChiKey: TZQXLCWSYQJGKV-YGLLJKSHSA-N

InChi: InChI=1S/C69H116N26O15S2/c1-5-36(3)53-64(109)90-45(30-52(99)100)61(106)88-43(22-14-26-82-68(76)77)60(105)94-54(37(4)6-2)65(110)95-34-40-19-11-10-18-39(40)29-47(95)63(108)86-33-51(98)92-55(56(71)101)48(23-15-27-83-69(78)79)112-111-35-46(91-57(102)41(70)20-12-24-80-66(72)73)62(107)89-44(28-38-16-8-7-9-17-38)58(103)85-31-49(96)84-32-50(97)87-42(59(104)93-53)21-13-25-81-67(74)75/h10-11,18-19,36-38,41-48,53-55H,5-9,12-17,20-35,70H2,1-4H3,(H2,71,101)(H,84,96)(H,85,103)(H,86,108)(H,87,97)(H,88,106)(H,89,107)(H,90,109)(H,91,102)(H,92,98)(H,93,104)(H,94,105)(H,99,100)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)(H4,78,79,83)/t36-,37-,41-,42+,43-,44-,45-,46-,47+,48+,53-,54-,55-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay. A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right.

In Vivo:

A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching. A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased.

Products are for research use only. Not for human use.