Description
12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity.
Product information
CAS Number: 54397-84-1
Molecular Weight: 280.40
Formula: C17H28O3
Chemical Name: (5Z,8E,10E,12S)-12-hydroxyheptadeca-5,8,10-trienoic acid
Smiles: CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(O)=O
InChiKey: KUKJHGXXZWHSBG-WBGSEQOASA-N
InChi: InChI=1S/C17H28O3/c1-2-3-10-13-16(18)14-11-8-6-4-5-7-9-12-15-17(19)20/h5-8,11,14,16,18H,2-4,9-10,12-13,15H2,1H3,(H,19,20)/b7-5-,8-6+,14-11+/t16-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
12S-HHT (0-150 nM; 3 hours) has anti-inflammatory activity by attenuating the UVB-induced IL-6 synthesis in HaCaT cells. 12S-HHT inhibits the UVB-stimulated p38 MAPK/NF-κB pathway by up-regulating MKP-1, which leads to the suppression of IL-6 synthesis. 12S-HHT is an endogenous agonist for BLT2.
Products are for research use only. Not for human use.
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