Description
Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.
Product information
CAS Number: 6211-32-1
Molecular Weight: 390.90
Formula: C21H27ClN2O3
Chemical Name: methyl (1S, 2S, 4aS, 13bS, 14aS)-2-hydroxy-1, 2, 3, 4, 4a, 5, 7, 8, 13, 13b, 14, 14a-dodecahydroindolo[2', 3':3, 4]pyrido[1, 2-b]isoquinoline-1-carboxylate hydrochloride
Smiles: Cl.COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCC4C5=CC=CC=C5NC=4[C@@H]3C[C@@H]21
InChiKey: PIPZGJSEDRMUAW-ZKKXXTDSSA-N
InChi: InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15+,17+,18+,19+;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 6 mg/mL (15.35 mM; Need ultrasonic). H2O : 5 mg/mL (12.79 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
[3H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [3H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes. [3H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors. When using [3H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (Ki human=14.3 nM, Ki rat=35.8 nM). Saturation studies shows that the affinity of [3H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) .
Products are for research use only. Not for human use.
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