1α-Hydroxy-3-epi-vitamin D3

1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion.

Product information

CAS Number: 58028-00-5

Molecular Weight: 400.64

Formula: C27H44O2

Chemical Name: (1S, 3S, 5Z)-5-{2-[(1R, 3aS, 4E, 7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1, 3-diol

Smiles: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(/CCC[C@@]21C)=C/C=C1/C[C@H](O)C[C@H](O)C/1=C

InChiKey: OFHCOWSQAMBJIW-NIZRVZOPSA-N

InChi: InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23+,24-,25+,26+,27-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

1 alpha, 25(OH)2D3 is an important negative regulator of parathyroid hormone (PTH) gene transcription. In ROS 17/2.8 cells, 1α-OHD3 (10 μM) not only metabolized into 1αOH-3-epi-D3 and 1α,25(OH)2D3 but also 1α,25(OH)2-3-epi-D3.

Products are for research use only. Not for human use.