Description
DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH.
Product information
CAS Number: 2511248-11-4
Molecular Weight: 436.48
Formula: C24H25FN4O3
Chemical Name: 6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4, 5-dihydro-1H-1, 2, 4-triazol-1-yl]-7-fluoro-2-(2-methylphenyl)-4-(propan-2-yl)-1, 2-dihydroisoquinolin-1-one
Smiles: CC1=CC=CC=C1N1C=C(C(C)C)C2=CC(=C(F)C=C2C1=O)N1N=C(CO)N(CC)C1=O
InChiKey: BZKHQYHQHLKJNX-UHFFFAOYSA-N
InChi: InChI=1S/C24H25FN4O3/c1-5-27-22(13-30)26-29(24(27)32)21-11-16-17(10-19(21)25)23(31)28(12-18(16)14(2)3)20-9-7-6-8-15(20)4/h6-12,14,30H,5,13H2,1-4H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DHODH-IN-16 (Example 22) potently inhibits the growth of MOLM-13 cells with an IC50 of 0.2 nM.
Products are for research use only. Not for human use.
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