Description
Seletracetam (Ucb 44212) lithium, as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
Product information
Molecular Weight: 239.17
Formula: C10H14F2LiN2O2
Chemical Name: (S)-2-((S)-4-(2, 2-difluorovinyl)-2-oxopyrrolidin-1-yl)butanamide, lithium salt
Smiles: [Li].CC[C@@H](C(N)=O)N1C[C@@H](CC1=O)C=C(F)F |^1:0|
InChiKey: HJQBNXXVSPVJMF-HHQFNNIRSA-N
InChi: InChI=1S/C10H14F2N2O2.Li/c1-2-7(10(13)16)14-5-6(3-8(11)12)4-9(14)15;/h3,6-7H,2,4-5H2,1H3,(H2,13,16);/t6-,7+;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Seletracetam lithium decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A. Seletracetam lithium decreases synaptic responses in a time-, frequency- and concentration-dependent manner. Seletracetam lithium modifies rates of presynaptic release. Seletracetam lithium inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro.
Products are for research use only. Not for human use.
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