NVS-PI3-4


Catalog No. Size PriceQuantity
M16394-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases.

Product information

CAS Number: 941580-60-5

Molecular Weight: 402.51

Formula: C20H26N4O3S

Chemical Name: 3-({[5-(4-acetylphenyl)-4-methyl-1,3-thiazol-2-yl]carbamoyl}amino)-N-tert-butylpropanamide

Smiles: CC(=O)C1=CC=C(C=C1)C1SC(NC(=O)NCCC(=O)NC(C)(C)C)=NC=1C

InChiKey: IUPXLLWDLOWEBR-UHFFFAOYSA-N

InChi: InChI=1S/C20H26N4O3S/c1-12-17(15-8-6-14(7-9-15)13(2)25)28-19(22-12)23-18(27)21-11-10-16(26)24-20(3,4)5/h6-9H,10-11H2,1-5H3,(H,24,26)(H2,21,22,23,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (621.10 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells.

Products are for research use only. Not for human use.

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