Description
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion.
Product information
CAS Number: 162112-37-0
Molecular Weight: 410.41
Formula: C18H17F3N4O2S
Chemical Name: N-(3-hydroxypropyl)-5-methyl-1-{4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-1H-pyrazole-4-carboxamide
Smiles: CC1=C(C=NN1C1=NC(=CS1)C1=CC(=CC=C1)C(F)(F)F)C(=O)NCCCO
InChiKey: HOFGTYCLOKDAES-UHFFFAOYSA-N
InChi: InChI=1S/C18H17F3N4O2S/c1-11-14(16(27)22-6-3-7-26)9-23-25(11)17-24-15(10-28-17)12-4-2-5-13(8-12)18(19,20)21/h2,4-5,8-10,26H,3,6-7H2,1H3,(H,22,27)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (609.15 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1. RWJ 50271 inhibits both human and murine NK activity (IC50=5.0 μM) in an LFA-1/ICAM-1-dependent natural killer [NK] cytotoxicity assay. RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X or VLA-4/VCAM-1-mediated cell adhesion up to 20 μM concentrations. RWJ 50271 does not alter the LFA-1 expression levels on HL60 cells. RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1. RWJ 50271 does not exhibit any toxic activity up to 100 μM concentrations.
In Vivo:
RWJ 50271 (50 mg/kg; p.o.) is effective in animal model of inflammation.
Products are for research use only. Not for human use.
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