Description
cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively.
Product information
CAS Number: 477331-06-9
Molecular Weight: 173.17
Formula: C7H11NO4
Chemical Name: (1R, 3R)-1-aminocyclopentane-1, 3-dicarboxylic acid
Smiles: N[C@]1(C[C@@H](CC1)C(O)=O)C(O)=O
InChiKey: YFYNOWXBIBKGHB-CLZZGJSISA-N
InChi: InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
cis-ACPD is a selective group II mGluR agonist, with EC50s of 13, 50, >300 and >300 μM for mGluR2, mGluR4, mGluR1 and mGluR5, respectively. cis-ACPD (1-1000 µM; 60 min) stimulates hydrolysis of 3H-phosphoinositide.
In Vivo:
cis-ACPD (1-1000 mg/kg; i.p.) produces dose-related convulsions in rats.
Products are for research use only. Not for human use.
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