CDK8-IN-1


Catalog No. Size PriceQuantity
M16841-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

Product information

CAS Number: 1629633-48-2

Molecular Weight: 255.20

Formula: C11H8F3N3O

Chemical Name: 4-(pyridin-4-yl)-3-(trifluoromethyl)-1H-pyrrole-2-carboxamide

Smiles: NC(=O)C1NC=C(C=1C(F)(F)F)C1C=CN=CC=1

InChiKey: RKTPHHQXNCHBCF-UHFFFAOYSA-N

InChi: InChI=1S/C11H8F3N3O/c12-11(13,14)8-7(5-17-9(8)10(15)18)6-1-3-16-4-2-6/h1-5,17H,(H2,15,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively.

Products are for research use only. Not for human use.

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