Description
CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
Product information
CAS Number: 1629633-48-2
Molecular Weight: 255.20
Formula: C11H8F3N3O
Chemical Name: 4-(pyridin-4-yl)-3-(trifluoromethyl)-1H-pyrrole-2-carboxamide
Smiles: NC(=O)C1NC=C(C=1C(F)(F)F)C1C=CN=CC=1
InChiKey: RKTPHHQXNCHBCF-UHFFFAOYSA-N
InChi: InChI=1S/C11H8F3N3O/c12-11(13,14)8-7(5-17-9(8)10(15)18)6-1-3-16-4-2-6/h1-5,17H,(H2,15,18)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively.
Products are for research use only. Not for human use.
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