HKSOX-1m (5/6-mixture) (hydrobromide)

HKSOX-1m (5/6-mixture) hydrobromide is a O2•− fluorescent probe for mitochondria-targeting, exhibiting excellent selectivity and sensitivity toward O2•− over a broad range of pH, strong oxidants, and abundant reductants found in cells.

Product information

Molecular Weight: 2517.44

Formula: C98H74Br4F20N4O20P2S4

Chemical Name: triphenyl(4-(4-(2', 4', 5', 7'-tetrafluoro-3-oxo-3', 6'-bis(((trifluoromethyl)sulfonyl)oxy)-3H-spiro[isobenzofuran-1, 9'-xanthene]-5-carbonyl)piperazin-1-yl)butyl)phosphonium triphenyl(4-(4-(2', 4', 5', 7'-tetrafluoro-3-oxo-3', 6'-bis(((trifluoromethyl)sulfonyl)oxy)-3H-spiro[isobenzofuran-1, 9'-xanthene]-6-carbonyl)piperazin-1-yl)butyl)phosphonium bromide dihydrobromide

Smiles: [Br-].[Br-].Br.Br.O=C1OC2(C3=CC(F)=C(OS(=O)(=O)C(F)(F)F)C(F)=C3OC3=C2C=C(F)C(OS(=O)(=O)C(F)(F)F)=C3F)C2C=C(C=CC1=2)C(=O)N1CCN(CC1)CCCC[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.O=C(C1C=C2C(=CC=1)C1(OC2=O)C2C=C(F)C(OS(=O)(=O)C(F)(F)F)=C(F)C=2OC2=C1C=C(F)C(OS(=O)(=O)C(F)(F)F)=C2F)N1CCN(CC1)CCCC[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1

InChiKey: BYOVJHJLFIAGRN-UHFFFAOYSA-L

InChi: InChI=1S/2C49H36F10N2O10PS2.4BrH/c50-37-27-35-41(39(52)43(37)70-73(64,65)48(54,55)56)68-42-36(28-38(51)44(40(42)53)71-74(66,67)49(57,58)59)47(35)34-19-18-29(26-33(34)46(63)69-47)45(62)61-23-21-60(22-24-61)20-10-11-25-72(30-12-4-1-5-13-30,31-14-6-2-7-15-31)32-16-8-3-9-17-32;50-37-27-35-41(39(52)43(37)70-73(64,65)48(54,55)56)68-42-36(28-38(51)44(40(42)53)71-74(66,67)49(57,58)59)47(35)34-26-29(18-19-33(34)46(63)69-47)45(62)61-23-21-60(22-24-61)20-10-11-25-72(30-12-4-1-5-13-30,31-14-6-2-7-15-31)32-16-8-3-9-17-32;;;;/h2*1-9,12-19,26-28H,10-11,20-25H2;4*1H/q2*+1;;;;/p-2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

HKSOX-1m (5/6-mixture) hydrobromide (10 μM) sensitively captures signals for basal and Antimycin A (1 μM)-stimulated mitochondrial O2•− in differentiated human THP-1 cells, at very low laser power output (1% intensity at Ex 514 nm on Zeiss LSM 510 Meta).

Products are for research use only. Not for human use.