Description
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced TrkB activity with an IC50 of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects.
Product information
Molecular Weight: 1314.39
Formula: C50H74F3N13O19S3
Chemical Name: (3S, 9S, 12S, 15S, 18S, 24R, 29R, 32S, 37aS)-29-amino-32-(2-amino-2-oxoethyl)-15-(4-aminobutyl)-18-(2-carboxyethyl)-9-(4-hydroxybenzyl)-12-((R)-1-hydroxyethyl)-3-(2-(methylthio)ethyl)-1, 4, 7, 10, 13, 16, 19, 22, 30, 33-decaoxotetratriacontahydro-1H-pyrrolo[2, 1-b1][1, 2]dithia[5, 8, 11, 14, 17, 20, 23, 26, 29, 32]decaazacyclopentatriacontine-24-carboxylic acid--2, 2, 2-trifluoroacetic acid (1/1)
Smiles: C[C@@H](O)[C@@H]1NC(=O)[C@H](CC2C=CC(O)=CC=2)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC1=O)C(O)=O.OC(=O)C(F)(F)F
InChiKey: OZUSCKXPVMHCDG-LRWVIUNESA-N
InChi: InChI=1S/C48H73N13O17S3.C2HF3O2/c1-24(62)39-46(75)58-28(6-3-4-15-49)43(72)56-29(12-13-38(67)68)41(70)52-21-37(66)55-33(48(77)78)23-81-80-22-27(50)40(69)59-32(19-35(51)64)47(76)61-16-5-7-34(61)45(74)57-30(14-17-79-2)42(71)53-20-36(65)54-31(44(73)60-39)18-25-8-10-26(63)11-9-25;3-2(4,5)1(6)7/h8-11,24,27-34,39,62-63H,3-7,12-23,49-50H2,1-2H3,(H2,51,64)(H,52,70)(H,53,71)(H,54,65)(H,55,66)(H,56,72)(H,57,74)(H,58,75)(H,59,69)(H,60,73)(H,67,68)(H,77,78);(H,6,7)/t24-,27+,28+,29+,30+,31+,32+,33+,34+,39+;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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