2', 3'-cGAMP-C2-PPA

2',3'-cGAMP-C2-PPA (45), A cyclic di-nucleotide, is a STING agonist (US20210015941A1). 2',3'-cGAMP-C2-PPA is a drug-linker conjugate for ADC that can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

Product information

CAS Number: 2586047-11-0

Molecular Weight: 850.71

Formula: C27H36N10O14P2S2

Chemical Name: 4-((2-((5S, 7R, 8R, 12aR, 14R, 15R, 15aS, 16R)-7-(2-amino-6-oxo-3, 6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2, 10, 15-trihydroxy-2, 10-dioxidooctahydro-12H-5, 8-methanofuro[3, 2-l][1, 3, 6, 9, 11]pentaoxa[2, 10]diphosphacyclotetradecin-16-yl)ethyl)disulfaneyl)pentanoic acid

Smiles: CC(CCC(O)=O)SSCC[C@H]1[C@H]2OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3OP(O)(=O)OC[C@H]1O[C@H]2N1C=NC2=C1NC(N)=NC2=O)N1C=NC2=C1N=CN=C2N

InChiKey: IBPLNKRENHFZJM-AYPAWVCOSA-N

InChi: InChI=1S/C27H36N10O14P2S2/c1-11(2-3-15(38)39)55-54-5-4-12-13-6-46-53(44,45)51-20-14(49-25(18(20)40)36-9-32-16-21(28)30-8-31-22(16)36)7-47-52(42,43)50-19(12)26(48-13)37-10-33-17-23(37)34-27(29)35-24(17)41/h8-14,18-20,25-26,40H,2-7H2,1H3,(H,38,39)(H,42,43)(H,44,45)(H2,28,30,31)(H3,29,34,35,41)/t11?,12-,13-,14-,18-,19-,20-,25-,26-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.