Description
CCX354 is an antagonist of CCR1, with anti-inflammatory activity.
Product information
CAS Number: 1010073-75-2
Molecular Weight: 451.91
Formula: C22H22ClN7O2
Chemical Name: 1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]ethan-1-one
Smiles: COC1=CC(=CC=C1Cl)N1CCN(CC1)C(=O)CN1N=C(C2NC=CN=2)C2=CC=CN=C12
InChiKey: ZIMLRKWQDLVPEK-UHFFFAOYSA-N
InChi: InChI=1S/C22H22ClN7O2/c1-32-18-13-15(4-5-17(18)23)28-9-11-29(12-10-28)19(31)14-30-22-16(3-2-6-26-22)20(27-30)21-24-7-8-25-21/h2-8,13H,9-12,14H2,1H3,(H,24,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CCX354 shows potent activities in the chemotaxis assay, with IC50 < 100 nM.
In Vivo:
In vivo, CCX354 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties.
Products are for research use only. Not for human use.
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