CCX354


Catalog No. Size PriceQuantity
M17117-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CCX354 is an antagonist of CCR1, with anti-inflammatory activity.

Product information

CAS Number: 1010073-75-2

Molecular Weight: 451.91

Formula: C22H22ClN7O2

Chemical Name: 1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]ethan-1-one

Smiles: COC1=CC(=CC=C1Cl)N1CCN(CC1)C(=O)CN1N=C(C2NC=CN=2)C2=CC=CN=C12

InChiKey: ZIMLRKWQDLVPEK-UHFFFAOYSA-N

InChi: InChI=1S/C22H22ClN7O2/c1-32-18-13-15(4-5-17(18)23)28-9-11-29(12-10-28)19(31)14-30-22-16(3-2-6-26-22)20(27-30)21-24-7-8-25-21/h2-8,13H,9-12,14H2,1H3,(H,24,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CCX354 shows potent activities in the chemotaxis assay, with IC50 < 100 nM.

In Vivo:

In vivo, CCX354 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties.

Products are for research use only. Not for human use.

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