Description
Ciprofloxacin monohydrochloride (Bay-09867 monohydrochloride) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
Product information
CAS Number: 93107-08-5
Molecular Weight: 367.80
Formula: C17H19ClFN3O3
Chemical Name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
Smiles: Cl.OC(=O)C1=CN(C2CC2)C2C=C(C(F)=CC=2C1=O)N1CCNCC1
InChiKey: DIOIOSKKIYDRIQ-UHFFFAOYSA-N
InChi: InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 5 mg/mL (13.59 mM; Need ultrasonic). H2O : 25 mg/mL (67.97 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin monohydrochloride (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL.
In Vivo:
Ciprofloxacin monohydrochloride (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin monohydrochloride (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin monohydrochloride (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin monohydrochloride. Intraperitoneal Ciprofloxacin monohydrochloride reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.
Products are for research use only. Not for human use.
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