Bopindolol

Bopindolol is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol is a prodrug of pindolol and can be used for essential and renovascular hypertension research.

Product information

CAS Number: 62658-63-3

Molecular Weight: 380.48

Formula: C23H28N2O3

Chemical Name: 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate

Smiles: CC1=CC2C(=CC=CC=2N1)OCC(CNC(C)(C)C)OC(=O)C1C=CC=CC=1

InChiKey: UUOJIACWOAYWEZ-UHFFFAOYSA-N

InChi: InChI=1S/C23H28N2O3/c1-16-13-19-20(25-16)11-8-12-21(19)27-15-18(14-24-23(2,3)4)28-22(26)17-9-6-5-7-10-17/h5-13,18,24-25H,14-15H2,1-4H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Bopindolol (intravenous injection; l8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs. Bopindolol (intraperitoneal injection; 3.0 mg/kg) reduced the diastolic blood pressure (DBP) in pithed rats. And pindolol (1.0 mg/kg) produced similar decreases in DBP of about 8 mmHg. it also produces a dose-dependent decrease in heart rate.

Products are for research use only. Not for human use.