Description
BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC50 of 1.5 nM in BACE-1 enzymatic assay.
Product information
Molecular Weight: 467.42
Formula: C21H21F4N5O3
Chemical Name: N-[3-[(4aS, 6S, 8aS)-2-amino-3, 3-difluoro-6-methyl-4a, 5, 6, 8-tetrahydro-4H-pyrano[3, 4-b]pyridin-8a-yl]-4-fluorophenyl]-5-(fluoromethoxy)pyrazine-2-carboxamide
Smiles: C[C@H]1C[C@H]2CC(F)(F)C(N)=N[C@]2(CO1)C1=CC(=CC=C1F)NC(=O)C1=CN=C(C=N1)OCF
InChiKey: QQHWYFAIJDVZQX-PVUDRZGPSA-N
InChi: InChI=1S/C21H21F4N5O3/c1-11-4-12-6-21(24,25)19(26)30-20(12,9-32-11)14-5-13(2-3-15(14)23)29-18(31)16-7-28-17(8-27-16)33-10-22/h2-3,5,7-8,11-12H,4,6,9-10H2,1H3,(H2,26,30)(H,29,31)/t11-,12-,20-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BACE-1 inhibitor 2 inhibits Aβ42 production in human neuroblastoma cell lines with an IC50 of 3.5 nM.
Products are for research use only. Not for human use.
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