Cadein1


Catalog No. Size PriceQuantity
M17586-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53.

Product information

Molecular Weight: 655.64

Formula: C33H48F2INO2

Chemical Name: 2-(2, 6-difluorobenzyl)-6, 7-dimethoxy-1-pentadecyl-3, 4-dihydroisoquinolin-2-ium iodide

Smiles: [I-].CCCCCCCCCCCCCCCC1C2=CC(OC)=C(C=C2CC[N+]=1CC1C(F)=CC=CC=1F)OC

InChiKey: NBXOVBALHDBUPW-UHFFFAOYSA-M

InChi: InChI=1S/C33H48F2NO2.HI/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-31-27-24-33(38-3)32(37-2)23-26(27)21-22-36(31)25-28-29(34)18-17-19-30(28)35;/h17-19,23-24H,4-16,20-22,25H2,1-3H3;1H/q+1;/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR. Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells .

Products are for research use only. Not for human use.

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