Description
JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.
Product information
Molecular Weight: 1620.73
Formula: C71H92F3N19O18S2
Chemical Name: (S)-3-((S)-2-((S)-1-(((4R, 10S, 13S, 16R, 19S, 22S, 25S)-19-((1H-imidazol-4-yl)methyl)-10-((1H-indol-3-yl)methyl)-22-(2-carboxyethyl)-13-(3-guanidinopropyl)-25-methyl-16-(naphthalen-2-ylmethyl)-6, 9, 12, 15, 18, 21, 24-heptaoxo-1, 2-dithia-5, 8, 11, 14, 17, 20, 23-heptaazacyclopentacosane-4-carbonyl)-L-prolyl)pyrrolidine-2-carboxamido)-6-aminohexanamido)-4-amino-4-oxobutanoic acid--2, 2, 2-trifluoroacetic acid (1/1)
Smiles: C[C@@H]1SSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=CC=CC=C23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(N)=O.OC(=O)C(F)(F)F
InChiKey: HCIVOFMTMCHGJQ-FBCOZVNTSA-N
InChi: InChI=1S/C69H91N19O16S2.C2HF3O2/c1-37-59(95)80-47(21-22-56(90)91)63(99)86-51(30-42-33-74-36-78-42)65(101)84-49(28-38-19-20-39-11-2-3-12-40(39)27-38)64(100)81-46(16-8-24-75-69(72)73)62(98)85-50(29-41-32-76-44-14-5-4-13-43(41)44)60(96)77-34-55(89)79-52(35-105-106-37)67(103)88-26-10-18-54(88)68(104)87-25-9-17-53(87)66(102)82-45(15-6-7-23-70)61(97)83-48(58(71)94)31-57(92)93;3-2(4,5)1(6)7/h2-5,11-14,19-20,27,32-33,36-37,45-54,76H,6-10,15-18,21-26,28-31,34-35,70H2,1H3,(H2,71,94)(H,74,78)(H,77,96)(H,79,89)(H,80,95)(H,81,100)(H,82,102)(H,83,97)(H,84,101)(H,85,98)(H,86,99)(H,90,91)(H,92,93)(H4,72,73,75);(H,6,7)/t37-,45-,46-,47-,48-,49+,50-,51-,52-,53-,54-;/m0./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.