Description
BM635 hydrochloride is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 hydrochloride has an MIC50 of 0.08 μM against M.tuberculosis H37Rv. BM635 hydrochloride doubles the in vivo exposure with respect to the free base BM635.
Product information
Molecular Weight: 428.97
Formula: C25H30ClFN2O
Chemical Name: 4-[[1-(4-fluorophenyl)-2-methyl-5-(4-propan-2-ylphenyl)pyrrol-3-yl]methyl]morpholine;hydrochloride
Smiles: Cl.CC1=C(CN2CCOCC2)C=C(C2C=CC(=CC=2)C(C)C)N1C1C=CC(F)=CC=1
InChiKey: JUVYBPYTCHPFBF-UHFFFAOYSA-N
InChi: InChI=1S/C25H29FN2O.ClH/c1-18(2)20-4-6-21(7-5-20)25-16-22(17-27-12-14-29-15-13-27)19(3)28(25)24-10-8-23(26)9-11-24;/h4-11,16,18H,12-15,17H2,1-3H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
BM635 hydrochloride (oral administration; 50 mg/Kg) results in gradual elevations in blood up to a Cmax of 579.1 ng/ml with Tmax of 3 hour. It doubles the in vivo exposure with respect to the free base BM635 in C57BL/6J mice.
Products are for research use only. Not for human use.
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