cGMP-HTL


Catalog No. Size PriceQuantity
M17709-C Contact sales@xcessbio.com for quotation $100

Description

cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy that contains a degradation tag (guanine derivatives) and a warhead to provide target specificity.

Product information

Molecular Weight: 844.27

Formula: C31H51ClN7O14PS

Chemical Name: (2R)-3-[[9-[(4aR, 6R, 7aR)-2, 7-dihydroxy-2-oxo-4a, 6, 7, 7a-tetrahydro-4H-furo[3, 2-d][1, 3, 2]dioxaphosphinin-6-yl]-2-amino-6-oxo-1H-purin-8-yl]sulfanyl]-2-acetamido-N-[2-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]propanamide

Smiles: CC(=O)N[C@@H](CSC1=NC2=C(N=C(N)NC2=O)N1[C@@H]1O[C@@H]2COP(O)(=O)O[C@@H]2C1O)C(=O)NCCOCCOCCOCCOCCOCCCCCCCl

InChiKey: FDOKYSQWSIEUBX-SGPGPASMSA-N

InChi: InChI=1S/C31H51ClN7O14PS/c1-20(40)35-21(27(42)34-7-9-47-11-13-49-15-17-50-16-14-48-12-10-46-8-5-3-2-4-6-32)19-55-31-36-23-26(37-30(33)38-28(23)43)39(31)29-24(41)25-22(52-29)18-51-54(44,45)53-25/h21-22,24-25,29,41H,2-19H2,1H3,(H,34,42)(H,35,40)(H,44,45)(H3,33,37,38,43)/t21-,22+,24?,25-,29+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

cGMP-HTL (10 μM, 24 h) selective degrades S-guanylated EGFP.

Products are for research use only. Not for human use.

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