SCO-267


Catalog No. Size PriceQuantity
M17825-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SCO-267 is an allosteric GPR40 full agonist. SCO-267 can be used for the research of chronic diseases including diabetes.

Product information

CAS Number: 1656261-09-4

Molecular Weight: 614.77

Formula: C36H46N4O5

Chemical Name: (3S)-3-cyclopropyl-3-{2-[(1-{2-[(2, 2-dimethylpropyl)(6-methylpyridin-2-yl)carbamoyl]-5-methoxyphenyl}piperidin-4-yl)methoxy]pyridin-4-yl}propanoic acid

Smiles: CC1=CC=CC(=N1)N(CC(C)(C)C)C(=O)C1=CC=C(C=C1N1CCC(COC2=CC(=CC=N2)[C@@H](CC(O)=O)C2CC2)CC1)OC

InChiKey: VVRXREQIOCYUKN-PMERELPUSA-N

InChi: InChI=1S/C36H46N4O5/c1-24-7-6-8-32(38-24)40(23-36(2,3)4)35(43)29-12-11-28(44-5)20-31(29)39-17-14-25(15-18-39)22-45-33-19-27(13-16-37-33)30(21-34(41)42)26-9-10-26/h6-8,11-13,16,19-20,25-26,30H,9-10,14-15,17-18,21-23H2,1-5H3,(H,41,42)/t30-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SCO-267 (CHO cells) activates the Gαq, Gαs, and Gα12/13 pathways and β-Arrestin Recruitment. SCO-267 is allosteric with fasiglifam and an endogenous ligand.

In Vivo:

SCO-267 (1 or 10 mg/kg; p.o.) improves insulin sensitivity and exerts sustained glucose-lowering effect.

Products are for research use only. Not for human use.

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